For example, the challenge room may feature the Teleport! If a Secret Room is next to a Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. item in the centre of the room. On the map, it is symbolized by an upright glowing white sword.
As with regular Challenge Rooms, If the room is adjacent to a secret room, you may also enter it by destroying the wall that separates the rooms.

Inside is an Angel room with an Angel Room pool prize. An Eternal Challenge Room is the Eternal variant of the Boss Challenge room, with the difference in that it has the health requirements of a regular challenge room. Notice however that, unless you have XRay Vision , the wall will close again when the fight begins. However, reentering the room and swapping out your Teleport! The door has a single glowing sword over it. Challenge rooms can only be entered if Isaac's total health (red, black, and soul hearts) is equal to or greater than his number of heart containers. However, the entrance to the Secret Room from the Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance. It is possible to pick up this item and immediately use it to avoid fighting the enemies. item back for the original item you left behind (if you swapped them upon pickup) will cause enemies to spawn. Upon picking up its contents, Isaac has to fight three waves of enemies. Like the Boss Room, taking the prize initiates the fight.